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Year : 2020  |  Volume : 11  |  Issue : 4  |  Page : 627-628  

Congenital melanocytic kissing nevus on right eyelid - A rare phenomenon

Department of Dermatology, Shree Krishna Hospital, Pramukhswami Medical College, Karamsad, Anand, Gujarat, India

Date of Web Publication13-Jul-2020

Correspondence Address:
Rita V Vora
Department of Dermatology, Shree Krishna Hospital, Pramukhswami Medical College, Karamsad - 388 325, Anand, Gujarat
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/idoj.IDOJ_481_19

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Congenital divided melanocytic nevus is a rare form of melanocytic nevus, which presents in the upper and lower eyelids on one side. It comes to existence due to genetic alteration in cells, which arise from mosaicism and only 30 cases have been reported till now. We present a rare case of 66 years old female with kissing nevus on right eyelids with no ophthalmological or functional disturbances.

Keywords: Eyelid, kissing nevus, melanocytic nevus

How to cite this article:
Vora RV, Shah AJ, Patel TB. Congenital melanocytic kissing nevus on right eyelid - A rare phenomenon. Indian Dermatol Online J 2020;11:627-8

How to cite this URL:
Vora RV, Shah AJ, Patel TB. Congenital melanocytic kissing nevus on right eyelid - A rare phenomenon. Indian Dermatol Online J [serial online] 2020 [cited 2022 Jan 26];11:627-8. Available from: https://www.idoj.in/text.asp?2020/11/4/627/289628

   Introduction Top

Melanocytic nevi are benign proliferations of melanocytic cells. Congenital divided melanocytic nevus is a rare form of melanocytic nevus, which presents in the upper and lower eyelids unilaterally. As this nevus extends up to the lid margins, its edges touch or “kiss” when the eyelids are closed. Although commonly presenting at birth, there have been cases where it appeared in later life. This occurs due to a rare embryological phenomenon and thus only 30 cases have been reported worldwide.[1]

   Case Report Top

A 66-year-old female presented to the skin OPD with history of having a painless, black colored, non-progressive swelling over right upper and lower eyelids since 40 years. The lesion caused difficulty in approximation of eyelids. On examination, there were brown-black colored uneven plaques with verrucous edges and hypertrichosis, covering approximately 80% of both right upper and lower eyelid margins on right side. [Figure 1] With the eyelid closed, both nevi acquired contiguity with their contact surfaces and resembled a single entity. [Figure 2] There was lower lid ectropion and slight ptosis on the right due to the nevus, but there were no other eye complaints. Conjunctiva, sclera, and cornea were spared from pigmentation and ophthalmic examination was normal.
Figure 1: Kissing nevus of the right eyelid

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Figure 2: With the eyelid closed, both nevi acquire contiguity with their contact surfaces and resemble a single entity

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   Discussion Top

Nevus, a Latin word for “maternal impression” or “birth mark,” indicates a circumscribed, nonneoplastic skin or mucosal lesion usually present at or soon after birth. Most congenital nevi are products of genetic alteration of cells, which arises from mosaicism. Melanocytic nevus, a type of nonvascular epidermal nevus, is a benign proliferation of melanocytic cells, which are arranged in nests in epidermis, dermis, or other tissue.[2] Although congenital melanocytic nevus develops during intrauterine life, the incidence of late congenital nevi can be explained by the inadequate production of melanin initially, or by small size of the nevus early on, which delays its detection.[3] Congenital divided nevus of the eyelids is a rare form, usually involving contiguous portions of the unilateral upper and lower eyelid margins, rendering the name “kissing nevus”. Normally, during intrauterine 6th week, the lids appear as ectodermal protrusions and grow toward each other and fuse at 24th week, after which they gradually separate. Melanoblasts originate from the neural crest and migrate during the 12–14 weeks of gestation to colonize the epidermis. During nevus formation, the defect in melanocyte migration or Schwann cell of neuroectodermal origin produces a split nevus.[4] This theory explains that it might be a single congenital nevus which has been divided due to developmental separation of eyelids. During developmental separation of eyelids, the single formed nevus undergoes a division and appears as two different entities. The nevi are usually asymptomatic and spare other eye structures, such as conjunctiva, sclera, and cornea.[5] In course of time there is a risk of malignant change (2% to 30%) in the nevus giving rise to malignant melanoma. Treatment options include dermabrasion, cryotherapy, excision, and skin grafting.[6] Multiple stage mosaic punching excision of the congenital divided nevus using a 10,600-nm CO2 pulsed laser has been performed in 15 cases in one of the study with good results.[6] Excision and blepharoplasty approach can also be used to treat such cases. Reconstruction can be done by various methods including the entire reconstructive ladder with both one- and two-staged approaches.[7]

   Conclusion Top

Congenital divided melanocytic nevus is a very rare clinical finding. We have presented a case of the so-called “kissing nevus” on right upper and lower eyelids, which appeared at the age of 20 years in a 66 year old female, without any functional deformity which was unusual.

Declaration of patient consent

The authors certify that they have obtained all appropriate patient consent forms. In the form the patient(s) has/have given his/her/their consent for his/her/their images and other clinical information to be reported in the journal. The patients understand that their names and initials will not be published and due efforts will be made to conceal their identity, but anonymity cannot be guaranteed.

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Conflicts of interest

There are no conflicts of interest.

   References Top

Rajput GC, Mahajan D, Chaudhary KP, Deewana V. Kissing naevus arising from neural crest cells presenting as upper and the lower lid mass. J Neurosci Rural Pract 2015;6:417-9.  Back to cited text no. 1
[PUBMED]  [Full text]  
Kincannon J, Boutzale C. The physiology of pigmented nevi. Pediatrics 1999;104:1042-5.  Back to cited text no. 2
Kovalyshyn I, Braun R, Marghoob A. Congenital melanocytic naevi. Dermatol 2009;50:231-40.  Back to cited text no. 3
Westfall CT, Shore JW, Rubin PA, Jakobiec FA. Kissing nevus masquerading as a viral papilloma. Ophthalmic Surg 1991;22:614-5.  Back to cited text no. 4
Alfano C, Chiummariello S, De Gado F, Fioramonti P, Bistoni G, Scuderi N. Divided nevus of the eyelids: Three case studies. In vivo 2007;21:137-40.  Back to cited text no. 5
Cho HJ, Lee W, Jeon MK, Park JO, Yang EJ. Staged mosaic punching excision of a kissing nevus on the eyelid. Aesthetic Plast Surg 2019;43:652-7.  Back to cited text no. 6
Desai SC, Walen S, Holds JB, Branham G. Divided nevus of the eyelid: Review of embryology, pathology and treatment. Am J Otolaryngol 2013;34:223-9.  Back to cited text no. 7


  [Figure 1], [Figure 2]


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