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  Table of Contents  
Year : 2015  |  Volume : 6  |  Issue : 5  |  Page : 356-357  

An indurated plantar plaque with surface nodularity

1 The Commonwealth Medical College, Scranton, PA, USA
2 The Ackerman Academy of Dermatopathology, New York, USA

Date of Web Publication4-Sep-2015

Correspondence Address:
Dirk M Elston
Ackerman Academy of Dermatopathology, 145 East 32nd Street, 10th Floor, New York, NY 10016
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Source of Support: Nil, Conflict of Interest: None declared.

DOI: 10.4103/2229-5178.164466

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How to cite this article:
Craig-Muller S, Elston DM. An indurated plantar plaque with surface nodularity. Indian Dermatol Online J 2015;6:356-7

How to cite this URL:
Craig-Muller S, Elston DM. An indurated plantar plaque with surface nodularity. Indian Dermatol Online J [serial online] 2015 [cited 2022 Jan 18];6:356-7. Available from: https://www.idoj.in/text.asp?2015/6/5/356/164466

A 65-year-old man presents with the lesions pictured [Figure 1], [Figure 2], [Figure 3].
Figure 1: Erythematous somewhat pearly indurated plaque on the plantar aspect of the foot. Focal nodularity was noted

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Figure 2: Fissured masses of pale pink material in the dermis (H and E, ×40)

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Figure 3: The fissured dermal material staining brick red with a Congo red stain (×40)

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The lesion most likely represents?

  1. Lipoid proteinosis
  2. Nodular amyloidosis (NA)
  3. Lichen amyloidosis (AL)
  4. Colloid milium
  5. Erythropoietic protoporphyria.

Nodular amyloidosis, also called primary cutaneous NA, is the rarest form of localized cutaneous AL.[1] NA demonstrate AL amyloid deposition usually limited to the skin, differentiating it from systemic AL.[2] The mean age of onset is 60 years,[3] but NA has been found to affect a broad age range and has no predilection for gender or ethnicity;[4],[5] NA tends to localize to the legs, hands, feet, trunk, and genitalia,[2],[6] Skin lesions appear as pink to red, deep, indurated, asymptomatic nodules. A waxy appearance and shades of yellow or orange may be noted.[7] Individual lesions range from a few millimeters to several centimeters in diameter, with typical lesions being a centimeter or more at the time of presentation.[8] Lesions can occasionally be bullous, anetodermic, or atrophic.[5] NA is classically asymptomatic with little or no pruritis, but hemorrhage may be noted due to capillary weakness from amyloid deposition.[2] The preoperative differential includes xanthoma, lymphoma cutis, cutaneous sarcoidosis, and keloid.[5]

Histopathologic examination reveals diffuse, homogenous, eosinophilic fissured amyloid deposits throughout the dermis.[9] Amyloid may also be noted in dermal blood vessels.[7] Plasma cells are commonly found at the periphery of the deposits.[7] Amyloid deposits characteristically stain brick red with the Congo red stain with apple-green birefringence under polarized microscopy.[6] Thioflavine T is highly sensitive for amyloid and demonstrates yellow-green fluorescence. Crystal violet is more commonly used for epidermally-derived amyloid and stains metachromatically purple.[7] Periodic acid-Schiff (PAS) positivity is also characteristic.

The histological differential diagnosis includes other conditions with eosinophilic deposits within the dermis. Lipoid proteinosis is characterized by deposition of hyaline material in the dermis, mucosa, and viscera.[5] Patients develop characteristic pearly papules at the ciliary margin of the eyelids. Pitted scarring is commonly present on the face, and the voice is gravelly because of infiltration of the vocal chords. Histologically, there is massive basement membrane thickening within the dermis, walls of blood vessels, and surrounding adnexal structures.[5] The deposits typically demonstrate a vertical orientation and are PAS positive and diastase resistant.[5] Macular amyloidosis (MA) and lichenoid amyloidosis (LA) are disorders characterized by deposition of epidermally-derived amyloid within the papillary dermis. The individual deposits are similar in size to civatte bodies and are typically surrounded by a network of melanin incontinence. Amyloid deposits in MA and LA are found only in the papillary dermis with no deeper penetration and no blood vessel involvement.[1] LA presents clinically with rows of discrete, hyperkeratotic brownish-red papules on the shins and lower legs.[1],[10] MA presents as a gray-brown, reticulated patch located on the upper back.[5] Both lesions may be pruritic.[2] Colloid millium presents clinically as translucent papules in sun-damaged areas, especially the rims of the auricular pinnae. Pink, fissured masses are noted in the upper dermis, and transition can be identified between elastotic fibers and the pink masses. Erythropoietic protoporphyria presents with indurated erythematous skin in sun-exposed areas, commonly beginning in childhood. Patients complain that their skin burns when exposed to sunlight. Histologically, dense pink mantles of basement membrane material are noted surrounding vessels in the upper third of the dermis.

Immunohistochemical studies have demonstrated that amyloid in NA is of the AL subtype, derived from immunoglobulin light chains.[7] Immunoperoxidase staining shows positivity for both kappa and lambda light chains.[1] Unlike MA and LA, NA amyloid does not label with antikeratin antibodies.[7]

Treatment has proven difficult with recurrence rates ranging from 7% to 50% following surgical excision.[1] Injections with triamcinolone have been noted to produce a paradoxical increase amyloid deposition.[6] Fortunately, the long-term prognosis is good as progression to systemic involvement is rare, but it is important to exclude systemic AL and plasma cell dyscrasia at the time of initial presentation.[2]

   References Top

Woollons A, Black MM. Nodular localized primary cutaneous amyloidosis: A long-term follow-up study. Br J Dermatol 2001;145:105-9.  Back to cited text no. 1
Terushkin V, Boyd KP, Patel RR, McLellan B. Primary localized cutaneous amyloidosis. Dermatol Online J 2013;19:20711.  Back to cited text no. 2
Moon AO, Calamia KT, Walsh JS. Nodular amyloidosis: Review and long-term follow-up of 16 cases. Arch Dermatol 2003;139:1157-9.  Back to cited text no. 3
Konopinski JC, Seyfer SJ, Robbins KL, Hsu S. A case of nodular cutaneous amyloidosis and review of the literature. Dermatol Online J 2013;19:10.  Back to cited text no. 4
Schwendiman MN, Beachkofsky TM, Wisco OJ, Owens NM, Hodson DS. Primary cutaneous nodular amyloidosis: Case report and review of the literature. Cutis 2009;84:87-92.  Back to cited text no. 5
Ritchie SA, Beachkofsky T, Schreml S, Gaspari A, Hivnor CM. Primary localized cutaneous nodular amyloidosis of the feet: A case report and review of the literature. Cutis 2014;93:89-94.  Back to cited text no. 6
Steciuk A, Dompmartin A, Troussard X, Verneuil L, Macro M, Comoz F, et al. Cutaneous amyloidosis and possible association with systemic amyloidosis. Int J Dermatol 2002;41:127-32.  Back to cited text no. 7
Fuenzalida H, Valenzuela F, Misad C. Nodular amyloidosis: Two clinical case reports. Clin Exp Dermatol 2009;34:92-4.  Back to cited text no. 8
Santos-Juanes J, Galache C, Curto JR, Astudillo A, Sánchez del Río J. Nodular primary localized cutaneous amyloidosis. J Eur Acad Dermatol Venereol 2004;18:224-6.  Back to cited text no. 9
Summers EM, Kendrick CG. Primary localized cutaneous nodular amyloidosis and CREST syndrome: A case report and review of the literature. Cutis 2008;82:55-9.  Back to cited text no. 10


  [Figure 1], [Figure 2], [Figure 3]


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