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Year : 2014  |  Volume : 5  |  Issue : 6  |  Page : 140-141  

Acral acanthosis nigricans (acral acanthotic anomaly)

1 Department of Dermatology, Katihar Medical College and Hospital, Katihar, Bihar, India
2 Department of Dermatology, Medical College and Hospital, Kolkata, West Bengal, India
3 Department of Pathology, Katihar Medical College and Hospital, Katihar, Bihar, India

Date of Web Publication5-Dec-2014

Correspondence Address:
Dr. Piyush Kumar
Department of Dermatology, Katihar Medical College and Hospital, Karim Bagh, Katihar - 854 105, Bihar
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/2229-5178.146201

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How to cite this article:
Anand V, Das A, Kumar P, Kumar R, Hassan S. Acral acanthosis nigricans (acral acanthotic anomaly). Indian Dermatol Online J 2014;5, Suppl S2:140-1

How to cite this URL:
Anand V, Das A, Kumar P, Kumar R, Hassan S. Acral acanthosis nigricans (acral acanthotic anomaly). Indian Dermatol Online J [serial online] 2014 [cited 2022 Jan 25];5, Suppl S2:140-1. Available from: https://www.idoj.in/text.asp?2014/5/6/140/146201

A 28-year-old female, apparently healthy and thinly built, presented with mildly itchy hyperpigmented hyperkeratotic plaques on her feet since three years. There were no systemic features suggestive of diabetes or other endocrinopathies associated with acanthosis nigricans (AN). She was not on any medication prior to onset of lesions. On examination, multiple well-defined hyperpigmented, hyperkeratotic plaques were present on the dorsum of several toes in a bilateral symmetrical manner [Figure 1]. Other skin sites, the scalp, palms, soles and mucosae were spared. Routine blood investigations, fasting and postprandial blood sugar and routine urine analysis were within normal limits. The liver enzymes, thyroid hormones and growth hormone were within normal range. Serum leptin and insulin level estimation could not be done as these were not available in our institute. Radiographic examination of the chest, skull and hands did not reveal any abnormality. Abdominal and pelvic ultrasonography was non-contributory. Biopsy of the skin showed hyperkeratosis, papillomatosis, increased pigmentation of the basal cell layer and mild acanthosis, with a sparse inflammatory infiltrate of mononuclear cells in the upper dermis [Figure 2]a and b. These histopathological findings were consistent with the diagnosis of AN. A final diagnosis of acral AN was made, considering clinical and histopathological findings.
Figure 1: Hyperpigmented hyperkeratotic plaques on dorsal surface of toes

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Figure 2: (a) Hyperkeratosis, acanthosis, papillomatosis and sparse mononuclear cell infiltration in dermis (H and E, ×40) (b) Higher magnification (H and E, ×100)

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AN is a common presentation in the out-patient department and usually affects the neck, axillae, groin, inner aspects of the thighs, flexor and extensor surface of the elbows and knees, dorsal joints of the hands, umbilicus and anus. Schwartz has categorized the entity into the following eight types: benign, malignant, associated with obesity, syndromic, unilateral, drug induced, mixed and acral. [1] In acral AN, also called as acral acanthotic anomaly, the lesions are localized to the knee, ankle, phalangeal joints and tarsophalangeal joints. [1] It is apparently more common in persons with a dark complexion and affects acral areas without prominent affection of axilla and other flexures. [2] The clinical significance of acral AN is ambiguous and more studies are needed to settle this issue. According to Schwartz, this type of AN essentially occurs in healthy black people and does not, on its own, call for a vigilant work-up of those afflicted; for the possible presence of an internal malignancy. However, recently it has been reported in association with dermatofibrosarcoma protuberans, non-Hodgkin's lymphoma [3] and gastric adenocarcinoma. [4]

Diagnosis is mostly clinical and can be confirmed by histopathology. In the majority of cases, improvement of the skin lesions is the primary concern of patients presenting to dermatologists. Treatment of its underlying condition often results in improvement of AN. The type occurring with obesity usually improves with weight loss. Etretinate, metformin, tretinoin, calcipotriol, urea, salicyclic acid, CO 2 laser ablation and long pulsed alexandrite laser therapy have been reported as successful treatments in individual cases. [1],[2]

   References Top

Schwartz RA. Acanthosis nigricans. J Am Acad Dermatol 1994;31:1-19;20.  Back to cited text no. 1
Schwartz RA. Acral acanthotic anomaly (AAA). J Am Acad Dermatol 1981;5:345-6.  Back to cited text no. 2
Song JY, Lim JH, Kim CW, Kim HO. A case of acral type acanthosis nigricans associated with lymphoma. Korean J Dermatol 2002;40:841-3.  Back to cited text no. 3
Lee SS, Jung NJ, Im M, Lee Y, Seo YJ, Lee JH. Acral-type Malignant Acanthosis Nigricans associated with gastric adenocarcinoma. Ann Dermatol 2011;23:S208-10.  Back to cited text no. 4


  [Figure 1], [Figure 2]

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